The story is about Fuse Kazuki is a member of Japan's heavily armed anti-terror police unit, Kerberos Panzer Cops. They are trained to defend and attack like ravenous, blindly loyal dogs - like Kerberos, the hellhound that guarded the gate to Hades. During a mission, however, Kazuki hesitates to shoot a young girl from a terrorist guerrilla group, leading to her suicide bombing. A troubled Kazuki is sent back to academy, during which time he gets pulled into a secretive Kerberos unit called Jin-Roh, or Wolf Brigade. He meets Kei, the older sister of the suicide bomber girl, and as the two grow closer, Kazuki realizes that they are both pawns in a greater rivalry between Kerberos and the Metro Police.
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